J.Jpn. Surg. Soc.. 87(5): 536-546, 1986

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Original article

HEMODYNAMIC CHANGE IN THE LIVER FOLLOWING HEPATIC RESECTION IN DOG.
－A COMPARATIVE STUDY BY ¹⁹⁸AU COLLOID METHOD, KICG AND H₂ CLEARANCE METHOD－

On the basis of our hypothesis that blood flow in the residual hepatic parenchyma is a determinant factor of posthepatectomy liver function, measurements were made of blood flow in the residual liver after 40％ hepatic resection indog. Adult mongrel dogs were divided into two groups, i.e., normal control and 40% hepatectomy, and evaluated for hepatic hemodynamics by ¹⁹⁸Au colloid method, KICG and H₂ clearance method. Blood biochemistry and, histology of the liver were also examincd.
The results are as follows : 1) In the control group, hepatic blood flow by ¹⁹⁸Au colloid method, KICG and H₂ clearance method was found to correlate significantly with each other. 2) In the 40％ hepatectomy group, the hepatic blood flow index by both ¹⁹⁸Au colloid method and KICG decreased in proportion to the amount of resected hepatic tissue initially and then increased as the liver regenerated. H₂ clearance method showed that hepatic blood flow per unit weight of tissue decreased in the face of reduced hepatic volume in early stage of posthepatectomy period and returned to the preoperative level as the liver regenerated.

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