J.Jpn. Surg. Soc.. 87(1): 10-19, 1986
Original article
A BASIC STUDY ON PLASMA EXCHANGE THERAPY FOR MALIGNANT TUMOR IN TUMOR BEARING RATS
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First Dept. of Surgery, Juntendo University, School of Medicine, Tokyo, Japan Masaaki Suzuki |
The subjects of this study were devided into four groups : (1) untreated group (control). (2) plasma exchange group (PE). (3) Mitomycin C treated group (MMC : active control) and (4) plasma exchange＋MMC treated group (combination therapy).
A tumor inhibiting effect was observed in the MMC and combination therapy groups, but was absent in the PE group. The survival-periods, however, were extended in the PE group, and to a significant extent in the combination therapy group.
α1acid glycoprotein (α1 AGP) whose plasma level is low in the normal, is demonstrated to increase linealy with the tumor load in the plasma of cancer-bearing rats. And it is observed to be decreased after plasma exchange.
Present basic studies suggested that plasma exchange alone has a survival-prolonging effect, but produces no inhibitory effect on tumor growth, and the combination therapy has a greater life-extending effect than plasma exchange alone or chemotherapy alone.
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