[
Abstract]
[
Full Text PDF] （in Japanese / 3092KB）
[Members Only And Two Factor Auth.] J.Jpn. Surg. Soc.. 86(12): 1618-1624, 1985
Original article
CYCLIC AMP-AND ATP-MEDIATED STIMULATION OF DNA SYNTHESIS FOLLOWING PARTIAL HEPATECTOMY BY PROSTAGLANDIN-E1 IN D-GALACTOSAMINE INJURED LIVER
D-galactosamine (D-gal) damaged rats were infused with Prostaglandin E
1 (PGE
1) through a peripheral vein for 40 min. before and after partial hepatectomy. DNA synthesis following 68% partial hepatectomy was severely inhibited by the pretreatment of D-galactosamine. PGE
1 infusion (0.5, 1.0μg/kg/min) enhanced the DNA synthesis inhibited by D-gal 600mg/kg significantly (p＜0.01). After 20 min. of PGE
1 infusion cyclic AMP levels of liver tissue was increased as compared with saline infusion in D-gal (600mg/kg)-damaged rat (p＜0.05). Also 20 min. and 3 hour after partial hepatectomy, ATP levels of liver tissue was enhanced in PGE
1 treated group (p＜0.05). However the doses of PGE
1 infused in this investigation could not increase the hepatic tissue blood flow measured by hydrogen gas clearance method. These results suggest that PGE
1 enhance DNA synthesis of injured liver after partial hepatectomy by the mechanism which PGE
1 stimulate cyclic AMP production and increase ATP level in hepatic tissue.
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