J.Jpn. Surg. Soc.. 86(8): 901-911, 1985

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Original article

COMBINED EFFECTS OF LOCAL HYPERTHERMIA, BLEOMYCIN, AND X-RAY ON EHRLICH ASCITES TUMOR IN MICE

The combined effects of local hyperthermia at 42.5℃ for 30 minutes (HTM), 1/10 LD₅₀ Bleomycin iv (BLM) and 200 rad-irradiation (200R) were studied in DDD strain male mice with Ehrlich ascites tumor. The objective was to acquire data on the optimum regimen for a combined administration of these 3 modalities. The treatments were carried out 10 days after the inoculation of 2×10⁶ of the cells into the right hind-limb. HTM was applied by water bath heating. Concomitant application of the 3 modalities led to the best effect with a 80% complete regression. A single modality produced no significant effect and a 30-50% regression occurred when 2 modalities were combined. To assess the influence of timing and sequence, HTM was applied at 1, 2, 4 and 6 hours before, after or simultaneously with the combination of BLM and 200R. A significant effect was obtained in case of simultaneous application of the 3 modalities and the effectiveness of HTM remained as long as the time interval between HTM and BLM plus 200R was 2 hours. This enhancement disappeared in case of 4 hour intervals.

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