J.Jpn. Surg. Soc.. 86(6): 709-716, 1985

---

Original article

SIGNIFICANCE OF CROSS-CIRCULATION ON OBSTRUCTIVE JAUNDICE IN RATS WITH SPECIAL REFERENCE TO THE MITOCHONDRIAL FUNCTION OF THE LIVER AND KIDNEY

Cross-circulation was performed to investigate the mitochondrial respiratory function of the liver and kidney in rats after 1, 2 and 3 weeks of biliary obstruction. Serum bilirubin and total bile acids concentration in blood in rats with biliary obstruction markedly decreased with 3 hours cross-circulation. There demonstrated, however, no significant change in mitochondrial function in the liver after crosscirculation. In contrast, mitochondrial function in the kidney showed significant improvement after 3 hours cross-circulation. Mitochondrial respiratory function in normal partner rats cross-circulation with jaundiced rats demonstrated temporal deterioration in the kidney and prolonged deterioration in the liver. It can be concluded that cross-circulation or plasma exchange might be useful for the prevention of renal failure in obstructive jaundice, since cross-circulation induced persistent improvement of the mitochondrial respiratory function in the kidney deteriorated by biliary obstruction.

---

---

To read the PDF file you will need Adobe Reader installed on your computer.