J.Jpn. Surg. Soc.. 86(4): 443-454, 1985
Original article
THE EFFECT OF Nd : YAG LASER IRRADIATION ON GASTRIC CANCERS IN RATS INDUCED BY N-METHYL-N’-NITRO-N-NITRO-SOGUANIDINE ; AS A MODEL OF ENDOSCOPIC LASER TREATMENT FOR EARLY GASTRIC CANCERS
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The Second Department of Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan Mitsuru Sasako |
Material and Method；in male rats of Wister strain, gastric cancers were induced by 30 weeks administration of 80mg/l MNNG solution. Then tumor bearing rats underwent laparotomy and gastrotomy, and tumors were irradiated by the Nd : YAG laser with 30W at the distance of 1cm, total energy ranging 120－1800 joules. These 20 stomachs were examined histologically ; 10 of them within 14 days, the rest more than 4 weeks after the irradiation.
CONCLUSION ; 1) Serial sections of resected stomachs proved perfectly that cancer tissue can be eradicated by Nd : YAG laser irradiation. 2) The photocoagulation effect of this laser had no specificity for gastric cancer tissue. 3) The process of its eradication are found as follows ; irradiated tissue is fallen into coagulation necrosis with surrounding normal tissue, then partially drops out and partially is replaced by granulation tissue which finally becomes fibrous tissue. 4) In the treatment of polypoid lesions, energy should be estimated per unit volume.
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