J.Jpn. Surg. Soc.. 86(3): 298-303, 1985
Original article
ACUTE GASTRIC ULCERATIONS IN RATS WITH OBSTRUCTIVE JAUNDICE－WITH SPECIAL REFERENCE TO GASTRIC MUCOSAL BLOOD FLOW
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The 1st Department of Surgery, Tohoku University School of Medicine, Tohoku, Japan Yoshio Konno, Jin-ichi Kameyama, Iwao Sasaki, Hideo Narui, Toshihiko Kamiyama |
One hundred and eighty-eight Spranque-Dawley rats weighing about 250g were prepared and divided into 4 groups as follows ; sham operation (control group), ligation of the bile duct (jaundiced group), vagotomy with pyloroplasty (vagotomized group), ligation of the bile duct and vagotomy with pyloroplasty (jaundiced and vagotomized group). After two weeks, water immersion and restraint stress procedures were performed in these 4 groups. The gravity of the gastric ulcerations was calculated by ulcerindex. The gastric mucosal blood flow was measured by hydrogen clearance technique.
The following results were obtained.
1. The control group showed increased ulcer index and decreased gastric mucosal blood flow after the stress procedures.
2. The jaundiced group showed significantly higher ulcer index and early, significant decrease of gastric mucosal blood flow compared to the control group after the stress procedures.
3. The vagotomized group showed significantly decreased ulcer index after stress procedures compared to the control group, however, the gastric mucosal blood flow were unchanged between both groups before and after the stress procedures.
4. The jaundiced and vagotomized group showed significant decrease of ulcer index and improvement of decrease of gastric mucosal blood flow compared to the jaundiced group. These data suggested that the significant decrease of gastric mucosal blood flow during the stress procedures was one of exacerbating factors of the acute gastric ulcerations in rats with obstructive jaundice, and vagotomy might prevent them by maintaining the gastric mucosal blood flow in obstructive jaundice.
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