J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 2839KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 85(12): 1570-1578, 1984

Original article

LITHOGENICITY OF BILE IN PATIENTS AFTER ILEAL RESECTION

Second Department of Surgery, Yokohama City University School of Medicine, Yokohama, Japan

Akira Nakano

Biliary lipid composition and lithogenicity were studied in 40 patients after ileal resection of different extent. The lithogenic index increased in extended ileal resection and ileostomy groups. There was a significant positive correlation between the lithogenic index and the length of ileal resection (r =0. 65, p＜0.001). Total bile acid concentration and the proportion of deoxycholic acid were decreased after ileal resections as compared to controls. Especially these changes were remarkable in the extended ileal resection and ileostomy groups (p＜0.001).
Nine out of 40 patients were restudied after one month of oral ursodeoxycholic acid administration (300mg/day). Ursodeoxycholic acid consistently reduced the lithogenicity by decreasing the proportion of cholesterol in bile. Ursodeoxycholic acid was useful reducing bile lithogenicity in patients whose bile was supersaturated after ileal resection.

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