J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 5257KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 85(8): 811-819, 1984

Original article

MORPHOLOGICAL AND IMMUNOCYTOCHEMICAL STUDIES OF PANCREATIC MULTIPLE ENDOCRINE NEOPLASIA TYPE-1

1) Department of Surgery, School of Medicine, Kanazawa University, Kanazawa, Japan
2) Second First Department of Sargery, Fukui Medical College, Fukui, Japan

Utaka Yonemura1), Kouji Konishi1), Ithuo Miazaki1), Kooichi Miwa2)

Morphological and immunocytochemical studies of pancreatic material from a patient with multiple endocrine neoplasia type-1 revealed hyperplasia of islets, multiple microadenomas, adenomas and cancers. Cellular composition of the hyperplastic islets was almost normal but the enlargement of the size and increase of the numbers were observed. Furthermore, neoformation of islets from ducts were found here and there. These hyperplastic islets, microadenomas, adenomas and cancers merged into each other and some of these microadenomas demonstrated malignant pictures. Most of the microadenomas produced multiple peptide hormones, on the other hand some of these revealed a single hormonal activity.
These results show that the abnormality of the primordial cells of the pancreatic endocrine cells develops these lesion.

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