J.Jpn. Surg. Soc.. 85(4): 283-299, 1984

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Original article

SERUM LEVELS OF IMMUNOSUPPRESSIVE ACIDIC PROTEIN (IAP) IN VARIOUS DISEASE STATES AND ITS CLINICAL SIGNIFICANCE

The IAP level of sera from normal subjects and patients with various diseases were quantitatively measured by single radial immunodiffusion method. The mean IAP concentration in the sera from 152 normal individuals was 375.3±100.1μg/ml, whereas among 86 patients with benign diseases, the level in 26 patients with acute abdominal inflammation or rheumatoid arthritis was particularly higher than normal level.
The IAP level in 277 patients with carcinoma was 642.9±311.0μg/ml which carcinoma was about 2-hold higher than normal level, especially in the patient with lung, biliary tract and esophageal cancer. Following successful surgical resection of carcinoma, the IAP level gradually decreased to normal level, but in the recurrent cancer patients the level increased markedly again.
The changes of IAP level was quantitatively correlated with the serum level of-α₁-acidglycoprotein (α₁-AG). However, IAP level had relatively higher response more than that of α₁-AG in patients with inflammation and carcinoma. In gastric cancer patients, there was a good correlation between IAP in increased level and phytohemagglutinin response in peripheral lymphocytes.
The evidence suggests that IAP level is a good immunological marker, which is associated with the tumor progression, recurrent involvement and effectiveness of therapeutic programs.

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