J.Jpn. Surg. Soc.. 85(2): 110-118, 1984

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Original article

EXPERIMENTAL STUDIES ON COMBINED CHEMOTHERAPY WITH HYPERTHERMIA AND ETHANOL FOR ADVANCED ESOPHAGEAL CANCER II. EFFECTS OF COMBINED TREATMENTS ON TUMOR GROWTH IN TUMOR-BEARING MICE

The combined effects of local hyperthermia, bleomycin and ethanol were investigated using Lewis lung carcinoma (3LL) in female C57BL/6 mice and FM3A tumors in female C3H/He mice. The combined treatments were performed on days 4 and 7 or on days 4, 7 and 10 after tumor implantation. Hyperthermia at 43℃ for 60 min or 15mg/kg of bleomycin resulted in mild reductions of tumor growth, respectively, whereas hyperthermia at 41℃ for 60 min alone did not show antitumor effects. Synergistic effects were observed with 43℃ hyperthermia and bleomycin. Furthermore the effects were enhanced by the combined use of ethanol (10% ethanol, 0.05 ml, i.t.). The antitumor effects of combined treatments of 41℃ hyperthermia and bleomycin were not so remarkable as those of 43℃ hyperthermia and bleomycin. In the combination of 41℃ hyperthermia, bleomycin and ethanol, marked increase of antitumor effects was observed particularly in 3LL tumor. A possible application of these findings to clinical therapy for advanced esophageal cancer was discussed.

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