J.Jpn. Surg. Soc.. 84(12): 1220-1228, 1983
Original article
EFFECTS OF EXTRACORPOREALLY INDUCED SYSTEMIC HYPERTHERMIA ON CELL-MEDIATED IMMUNITY
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*) Department of Thoracic Surgery, Mie University School of Medicine Makoto Kimura*), Tsutomu Ooi*), Tamotsu Morimoto*), Toshihiko Yamazaki*), Isao Yada*), Hiroaki Chikusa*), Shoji Namikawa*), Hiroshi Yuasa*), Minoru Kusagawa*), Masaharu Hosoi**), Nobuo Kato**) |
The following results were obtained :
1) Lymphocytes, T-cells and IgGFcR + T-cells counts slightly decreased during the hyperthermotherapy in patients.
During initiation of the hyperthermotherapy (Rectal temp. 41.6~41.8°), ADCC activity, PHA, and Con-A induced lymphocyte blastogenesis were slightly depressed, while NK activity was slightly enhanced.
At the end of the hyperthermia, ADCC activity, lymphocyte blastogenesis and NK activity were extremely depressed.
2) In vitro, 1 hour of heating at more than 40°C extremely depressed ADCC activity. By heating at 42°C, ADCC activity was depressed depending on heating time, while NK activity was slightly enhanced for the first 10 minutes and then depressed depending on heating time.
The administration of anti-cancer drugs (MMC, 5-FU, ADM) did not affect NK activity at all during the heating at 42°C.
3) From these results, it is highly suggested that immunopotentiators should be used during extracorporeally induced systemic hyperthermia in order to make up for the depressed cell-mediated immunity.
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