J.Jpn. Surg. Soc.. 84(11): 1155-1160, 1983

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Original article

THE EFFECT OF CYSTEAMINE ON THE DUODENAL DEFENSE MECHANISM IN THE VAGOTOMIZED RATS
－Special Reference to the Parietal Cell Vagotomy with CO₂-Laser－

The parietal cell vagotomy with CO₂-Laser defocused beam has been developed and its efficacy was confirmed in cysteamine induced duodenal ulcer in rat. Rats were classified into the truncal, parietal cell and Laser vagotomy groups and control.
After cysteamine was administered, the change of the Brunner’s gland were examined histologically for each group. Duodenal ulcer was seen and the depletion of the Brunner’s glands was observed in all control rats. Duodenal ulcer formation was prevented in all vagotomized rats regardless of the type of vagotomy and the preservation of synthetic activity of the Brunner’s gland was noted. However, multiple gastric ulcer was seen in truncal vagotomy group. Laser vagotomy was done very easily and safely. It consumed much less time and prevented doudenal ulcer formation. It prevented the cysteamine induced duodenal ulcer formation in rats by preservation of the Brunner's gland activity.

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