J.Jpn. Surg. Soc.. 84(4): 328-335, 1983
Original article
IMMUNOHISTOCHEMICAL LOCALIZATION OF CARCINOEMBRYONIC ANTIGEN (CEA) IN GASTRIC CANCER
－A COMPARATIVE STUDY BETWEEN TISSUE CEA AND PLASMA CEA－
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Second Department of Surgery, Kurume University School of Medicine, Kurume, Japan Hiroyuki Nishida |
A comparative study between tissue CEA and plasma CEA was carried out. The results were as follows.
1) Plasma CEAw ere positive (over 2.5 ng/ml) in 46 cases (37%). The positive rate was parallel with the size of cancer (p＜0.05) and was higher in well-differentiated cancer.
2) as to tissue CEA, 87 specimens (85%) showed the varying degree (±, +, ++) of positive reaction.
3) CEA was localized in luminal border, cytoplasma and grandular lumen in well differentiated cancer, and only in cytoplasma in poorly differentiated cancer.
4) The positive rate of plasma CEA was parallel with the degree of positive reaction in tissue.
5) No significant histological difference was observed between strong positive reaction to tissue CEA and positive plasma CEA.
In the cases with moderate positive reaction to tissue CEA, however, the positivity of plasma CEA was significantly higher in the cases with α or β INF pattern and/or intermed stromal reaction. (p＜0.05).
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