J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 2421KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 84(4): 321-327, 1983

Original article

EFFECT OF ADJUVANT IMMUNOTHERAPY WITH NOCARDIA RUBRA CELL-WALL SKELETON ON LUNG CANCER

1) Second Department of surgery, Kyushu University Medical School, Fukuoka, Japan
2) Department of Chest Surgery, Kyushu Cancer Center, Fukuoka, Japan
3) Department of Surgery, National Minami-Fukuoka Sanatorium, Fukuoka, Japan
4) Department of Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
5) Osaka university, Osaka, Japan

Kosei Yasumoto1), Yukito Ichinose2), Hidemichi Yaita1), Koichi Tanaka2), Nobuyuki Hara2), Mitsuo Ohta2), Nobuo Hirota3), Kikuo Nomoto4), Kiyoshi Inokuchi1), Yuichi Yamamura5)

A randomized clinical trial of intrapleural Nocardia rubra cell-wall skeleton (N-CWS) followed by intradermal N-CWS was performed against lung cancer patients from November, 1977 to June 1981. Totally, 190 patients were entered into this trial. The N-CWS treatment was effective in terms of prolongation of remission duration against not only operable but also inoperable patients. However, significant improvement of survival rate was observed only in operable patients, especially curative+relatively curative resection-group (p＜0.05).
The mode of recurrence was classified as local recurrence and distant metastasis in the curative+relatively curative resection-group. The rates of distant metastasis were 34.1 and 17.6%, respectively, in the control and the N-CWS groups. The rate of local recurrence was 13.6% in the control group, however, no local recurrence was observed in the N-CWS group.
These results indicate the clinical effectiveness of the N-CWS treatment especially in curatively resectable lung cancer. No serious side effect was experienced during this trial.

<< To previous pageTo next page >>

To read the PDF file you will need Adobe Reader installed on your computer.