J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 1581KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 84(3): 232-236, 1983

Original article

CLINICAL FACTORS RELATING TO THE INCIDENCE OF POST-TRANSFUSION HEPATITIS FOLLOWING OPEN HEART SURGERY

First Department of Surgery, Nagasaki University School of Medicine, Nagasaki, Japan
*) Second Department of Surgery, Ohita Medical College, Ohita, Japan

Toshiyasu Kugimiya, Tadayuki Oka, Eisuke Kusaba, Kenichi Fukushima, Masayuki Kuroiwa, Masatake Takagi, Hisataka Miyagawa, Yuji Takagi, Masao Tomita, Joji Shirabe*), Kiyohiko Kaku*), Tetsuo Hadama*)

A retrospective study of post-transfusion hepatitis (PTH) has been made of 168 patients who had open-heart surgery between 1978 and 1981 at the Nagasaki University Hospital. The criteria of PTH was defmed as an elevation of SGPT over 50 units with more than 2 weeks duration that occurred later than 3 weeks after the transfudion. PTH developed in 27 of the 168 patients (16%) and 26 of them were of the non-A, non-B type. The statistical analysis of these patients demonstrated that the following clinical factors significantly incerased the incidence of PTH subsequent to open-heart surgery: (1) Use of plasma fractionating products made from pooled plasma, such as PPSB (p＜0.001). (2) A large amount of blood and blood component transfudion (over 21 units, p＜0.01). (3) Prolongation of the operation time (more than 330 minutes, p＜0.05), cardiopulmonary bypass time (more than 90 minutes, p＜0.05) and aortic cross-clamping time (more than 45 minuted, p＜0.01), and (4) Surgery for cardiac lesions with left heart overloads (p＜0.01).

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