J.Jpn. Surg. Soc.. 83(12): 1377-1386, 1982

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Original article

EFFECTS OF SINGLE BLEOMYCIN INJECTION INTO AORTIC ESOPHAGEAL ARTERY ON ESOPHAGEAL CARCINOMA EVALUATED BY HISTOPATHOLOGY AND DNA MEASUREMENT

In 28 out of 66 cases with esophageal carcinoma, the effects of single injection of BLEOMYCIN (BLM) 15 to 45mg into aortic esophageal artery on carcinoma tissue were histopathologically investigated with the determination of nuclear DNA content, as an index. The histological changes caused by BLM arterial injection were necrosis at the front of advancing carcinoma nests frequently with marked reactions of foreign body giant cells, histiocytes and interstitial fibrosis near the necrosis, in both the primary lesion and the metastasized lymph node. The nuclear determination revealed an increase in cells with much nuclear DNA content and a wider dispersion of nuclear DNA values which were distinctly recognized at the perinecrotic area and at the deepest invasion of carcinoma nests. It has been suggested that nuclear alterations occur in the DNA level even in cases where the histological effects were not obvious. The superiority of the effects of single BLM injection (30 to 45mg) over venous BLM injection (300mg), along with expect of effects on distant lymph node, were reported in the series.

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