J.Jpn. Surg. Soc.. 83(10): 1177-1189, 1982
Original article
EXPERIMENTAL STUDY ON POSTOPERATIVE ENERGY AND PROTEIN METABOLISM
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1st Department of Surgery, Niigata University School of Medicine (Director: Prof. Terukazu Muto) Mitsuaki Setsu |
Results obtained were as follows :
1) Incorporation of 14C-leucine and 14C-glucose into serum protein remarkably increased after surgery, indicating accelerated hepatic synthesis.
2) After surgery, incorporation of 14C from each substrate into serum albumin increased on the 4th day rather than on the 1st day. Accelerated synthesis of serum albumin stimulated by injury raised a suggestion of its correlation to preservation of plasma colloid osmotic pressure.
3) No significant changes in amino acids concentration of the liver were recognized after surgery.
4) Oxidation of 14C-glucose was not suppressed in the surgical diabetic state.
5) Oxidation of 14C-leucine remarkably increased postoperatively.
These results were considered to indicate that, in the postoperative state, increased protein catabolism might have occurred in order not only to supply precursor substances for gluconeogenesis but also to supply amino acids for intrahepatic protein synthesis and for the source of peripheral energy.
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