J.Jpn. Surg. Soc.. 83(8): 723-735, 1982

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Original article

STUDIES ON NITROGEN SPARING EFFECT OF POSTOPERATIVE PERIPHERAL AMINO ACID INFUSION THERAPY

To evaluate the effects of peripheral amino acid (a.a.) infusion therapies with or without nonprotein calories, the following parenteral regimens were performed on the patients who received abdominal surgery. Group-I (Control) : 5 % dextrose and lactated Ringer solutions (each 1,000ml/day). Group-II : 10% dextrose with minerals and vitamins 2,000ml/day, Group-III : 3% a.a. solutions (Vuj-N a.a. formula) 2,000ml/day, Group-IV: 3% a.a., 7.5% dextroses olutions 2,000ml/day, Group-V : 3% a.a., 7.5% dextrose solutions and 10% fat emulsions 500ml/day, Group-VI : 3% a.a., 7.5% dextrose+50% dextrose (equevalent calories to 10% fat emulsions 500ml). Each infusions were continued for five days following the operations. Changes in serum chemistries, plasma aminograms or nitrogen balance were studied among these groups.
To study basic problems, transverscolostomies were performed on the mongreal dogs, starved for 3 weeks only water supply. Three different parenteral regimens as indicated below were administered for 6 days after surgery. Group-I : 10% dextrose, 80ml/kg・day, Group-II : 3% a.a., 80ml/kg・day, Group-III : 3% a.a., 7.5% dextrose, 80ml/kg・day.
Changes in serum chemistries, serum insulin, plasma aminograms, nitrogen balance, or bursting strength and histology of anastomosed colon were studied.
Results indicated that eventhough, a.a. infusion alone far improved postoperative protein catabolism as compared with dextrose infusion alone, addition of nonprotein calories tended to improve nitrogen balance further with more favorable effect on wound healing.

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