J.Jpn. Surg. Soc.. 83(7): 658-664, 1982

---

Original article

EXPERIMENTAL STUDIES ON THE HEPATIC FRAGMENTS AUTOTRANSPLANTATION

Hepatic fragments minuted by the collagenase digestion method were simultaneously autotransplantated into the parenchyma of both spleen and pancreas. Morphology and function of the transplanted liver tissue were investigated for 4 months after transplantation. At 2 months after transplantation, the liver tissue proliferated in the splenic pulp. Although the hepatic sinusoids with endotherial cells were found, one cell thick plate which was normal hepatocyte structure was lacked in the spleen. On the other hand, in the liver tissue transplanted into the pancreas, the hepatic sinusoids and hepatic cell plate had shown nearly normal structure. Furthermore, after ICG intravenous administration, ICG was detected in the pancreatic juice of dogs underwent hepatic fragments transplantation, whereas ICG was not detected in the pancreatic juice of the normal control dogs. These results indicate that liver tissue in the pancreas was able to secrete the bile into the pancreatic duct. Therefore, it is stressed that ductal drainage system like the pancreatic duct is essential for the hepatic fragments transplantation, not only to secrete the bile but also to reconstruct nearly normal liver structure.

---

---

To read the PDF file you will need Adobe Reader installed on your computer.