J.Jpn. Surg. Soc.. 83(6): 582-592, 1982
Original article
ESTROGEN RECEPTOR AND EXPERIMENTAL PANCREATIC CANCER IN RATS
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First Department of Surgery, Osaka Clty University Medical School Katsusuke Satake, Takayuki Yoshimoto, Ryuichiro Mukai, Kaoru Umeyama |
The tissue estrogen receptor content was determined by the dextran coated charcoal method, using 2, 4, 6, 7-3Hestradiol-17β andwas expressed as femtomoles (fmol) of estradiol-17β bound per milligram of cytosol protein.
In this study, the estrogen receptor was considered positive with a concentration of over 3 fmol/mg protein and dissociation binding constant of less than 10-9M.
Tumorigenesis was observed in 32 of 40 male rats and in 13 of 16 female rats which lived over 150 days after DMBA implantation. Carcinogenesis were observed in 16 of the 40 males and 7 of the 16 females.
Estrogen receptor was detected in 7 of the 32 males and 6 of the 13 females or in 2 of 8 atypical ductal proliferations and 11 of 23 cancerous tissues including 3 tubular adenocarcinoma, 5 poorly differentiated adenocarcinoma and 3 undifferentiated carcinoma.
From this results, alteration of estrogen receptor level may play an important role in the development of pancreatic carcinoma.
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