J.Jpn. Surg. Soc.. 83(1): 96-112, 1982

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Original article

AUXILIARY PARTIAL AUTOTRANSPLANTATION OF CANINE LIVER

Auxiliary partial autotransplantation of canine liver was performed with complete revascularization of the graft. Liver graft which was composed of 30 or 40 per cent of total liver mass was placed in right paracolic gutter, and received both arterial and portal blood supply through transplant hepatic artery and portal vein. Internal or external biliary drainage was made. Dogs were classified into six groups by type of vascular anastomosis and situation of the remaining lobes.
In general, autografts received poor portal blood supply showed atrophy and autografts without remaining lobes could not sustain life so long. Best result was obtained from the group in which grafts received enough portal blood supply with handicapped remaining lobes. In this group, grafts showed hypertrophy and had almost normal histological appearance. On the contrary in remaining lobes, marked atrophy was observed and atrophy or necrosis of hepatocytes was seen histologically. In dog survived for 131 days, remaining lobes were replaced by fibrous tissue and hepatocytes were seldom seen. So life of this dog seemed to be supported by hypertrophied graft.
These results suggest that auxiliary liver graft can regenerate well and be life-supporting if portal blood supply is enogh and remaining lobes are handicapped.

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