J.Jpn. Surg. Soc.. 82(12): 1447-1454, 1981

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Original article

EXPERIMENTAL STUDIES ON AUTOTRANSPLANTATION OF PANCREATIC FRAGMENTS
-THEIR FUNCTION AND THE SITES OF TRANSPLANTATION

The most favorable site for transplanted pancreatic exocrine and endocrine tissue was evaluated. The pancreatic fragments were prepared by mincing and collagenase digestion and autotransplanted into either splenic pulp, portal vein or hepatic parenchyma in totally pancreatectomized dogs. In each site, the function of both exocrine and endocrine tissue was investigated. On 14th and 60th day after transplantation, glucose tolerance test and pancreozymin secretin test were performed. The following results were obtained.
In the intrasplenic or intraportal transplant, diabetes was ameliorated for about a year and iv-GTT showed nearly normal curves as compared to those of the intrahepatic thansplant. The splenic pulp and portal vein were considered for a suitable site to the endocrine tissue. However, in these sites exocrine function was not well preserved. In the intrahepatic transplant, sigificantly high amounts of pancreatic exocrine enzymes were detected in the bile and also high amylase concentration in the bile was observed after pancreozymin secretin load, although the endocrine function was not so well as those of the intrasplenic or intraportal transplant. These facts showed that transplantation of pancreatic exocrine tissue would be well established in the hepatic parenchyma where is the ductal drainage system as intrahepatic bile ducts.

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