J.Jpn. Surg. Soc.. 82(12): 1442-1446, 1981

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Original article

PLASMA AMINO ACID PATTERNS IN PATIENTS WITH LIVER DISEASE

In 24 cases of hepatic fibrosis, 43 of liver cirrhosis, 6 of obstructive jaundice and 5 of acute hepatic failure, plasma free amino acids were measured. The aminograms of these various liver diseases were comparatively analyzed. In all of these groups, plasma free amino acid patterns were abnormal. Reduced BCAA and increased AAA values caused the decrease of BCAA/AAA, molar ratio (MR), in all groups especially in hepatic failure. Plasma BCAA and AAA concentration, determining the MR of each group, varied from one to another, showing different aminograms which seemed to be dependent on different types of the hepatic disorders such as cholestasis, hepatic fibrosis and hepatic cell necrosis. MR was found toc orrelate with not only the value of ZTT, prothrombin time, K-ICG and NH₄CI tolerance test but the histological severity assesed by the estimation of the hepatic parenchymal cell volume. In summary, MR was considered to be an useful index for the evaluation of the degree of liver damage.

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