J.Jpn. Surg. Soc.. 82(8): 872-884, 1981
Original article
FOLLOW-UP STUDIES OF THE EXPERIMENTAL GASTRIC CANCER IN THE BEAGLES
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First Department of Surgery, Tokyo Medical and Dental University, School of Medicine (Chief: Prof. Matsucoshi Menjo) Akira Nakajima, M.D. |
Gastric cancer was produced by feeding 150mg/day of N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) for 3-12 months. Twenty-one dogs which developed cancer were used for the present study.
Follow-up studies included serial endoscopy and biopsy, and the animals were eventually oprated upon for resection of the stomach and/or sacrificed for histopathological examination.
The following results were obtained.
1. Speed of cancer growth was colsely correlated with the duration of ENNG administration. The longer the administration, the faster the rate of growth.
2. Red spot in the gastric mucosa which was observed immediatly after the start of ENNG appeared to be an important prodrome for minute cancer.
3. Ilb type minute cancer was predominantly observed within the 6-month period after completion of ENNG for 3-6 months.
4. In the well-differentiated adenocarcinomas, the growth tended to be a protruded type keeping a similar figure, while in the poorly differentiated cancer, a depressed or an excavated type was predominant.
5. In the two dogs, collision and/or confluence of multiple cancers was observed, which appeared to suggest a possible pathway leading to advanced cancer.
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