J.Jpn. Surg. Soc.. 82(7): 773-780, 1981

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Original article

ENDOGENOUS ENDOTOXEMIA IN RATS INDUCED BY TOTAL HEPATIC VASCULAR OCCLUSION

Studies have been made in rats with total hepatic vascular occlusion for 15 minutes to clarify the etiology, pathophysiology and treatments of the endotoxemia in liver diseases.A cause of the endotoxemia could be endogenous originated from intestinal bacteria via portal vein, since the higher detection of the endotoxin in portal blood than in peripheral blood was exhibited. In rats with previously suppressed reticuloendotherial system by splenectomy, an increased detection of the endotoxemia and a increased consumption of the complement were demonstrated. As for reason, it is considered that the damaged hepatic Kupffer cells function induced by ischemia which was not enough to compensate the suppression of the reticuloendotherial system resulted in marked deterioration of the phagocytic function. It was suggested that endotoxemia which was frequently seen in rats with ischemic liver without spleen would be atrributable to the dysfunction of the mitochondrial respiratory function both in the liver and the renal cortex.It is thus reasonable to assume that the endotoxemia is implicated in the induction of renal damage, since the thicking of mesangial cells in the glomeruli and the fibrinous deposition were also observed microscopically. The relative efficacy of Polymyxin B adminis tration for the endotoxemia was demonstrated.

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