J.Jpn. Surg. Soc.. 82(7): 748-758, 1981
Original article
CHANGES IN COMPOSITION OF FREE AMINO ACIDS IN BLOOD DURING REGENERATION PROCESS AFTER MAJOR HEPATECTOMY
|
First Department of Surgery, University of Hokkaido School of Medicine Toshihiko Tsuburaya |
The results were as follows.
1) All amino acids except Arg, Glu and Pro increased within one to five days after hepatectomy. During this period, histological findings of the remained liver revealed focal necrosis and hemorrhage.
2) The size and weight of the remnant liver increased rapidly during two to six weeks after hepatectomy. The pattern of the free amino acids showed the decrease in glucogenic amino acid in first half of this period and ketogenic amino acid in the latter.
3) In spite of normal findings of liver function tests and histology, free amino acids did not reveal normal pattern within eight weeks after major hepatectomy.
4) Eleven to twelve weeks after hepatectomy, the pattern of free amino acids returned to the normal as seen in the dog with non-resected liver.
These alterations persisted by the completion of the regeneration process.
It was concluded that the changes of the concentration and ratio of each amino acid in the blood after hepatectomy were well correlated with the function and regeneration process of the remained liver.
To read the PDF file you will need Adobe Reader installed on your computer.