J.Jpn. Surg. Soc.. 82(6): 671-680, 1981

---

Original article

THE ENDOCDINE FUNCTION OF THE PANCREAS AFTER PARTIAL PANCREATECTOMY

The effect of resection of the pancreas on insulin and glucagon secretion was studied in the partially pancreatectomized patient, with special reference to the resected size of the pancreas. The insulin secretion was significantly lowered after resection of 50 to 65 percent of pancreas below the preoperative level, being grossly proportional to the resected size of the pancreas. The insulin secretion remained at a low level after the surgery and failed to recover during the post-operative course up to 5 years. The glucagon secretion was also suppressed soon after the partial pancreatectomy. It is to be noted, however, that the glucagon secretion recovered with progress of post-operative days. Sandmeyer's diabetes was found in 4 cases of 21 patients in whom 65 percent of pancreas was removed. The insulin secretion was undetectable in these 4 cases during the glucose infusion. To the contrary, the glucagon secretion was preserved in these cases of Sandmeyer's diabetes. The presenting study indicates dissociation between the insulin secretion and glucagon secretion in the subtotally pancreatectomized patients.

---

---

To read the PDF file you will need Adobe Reader installed on your computer.