J.Jpn. Surg. Soc.. 82(5): 469-482, 1981

---

Original article

STUDIES ON BLOOD COAGULATION, FIBRINOLYSIS AND COMPLEMENTS IN PATIENTS WITH OBSTRUCTIVE JAUNDICE

Changes of coagulation, fibrinolysis and complements were investigated in sixtysix cases with obstructive jaundice. Hypercoagulable state, decreased fibrinolytic activities and high levels of complements were common features. Cases with suppurative cholangitis showed significant prolongation of activated partial thromboplastin time and prothrombin time, reduction of hepaplastin test values and decrease of antithrombin III and plasminogen levels in comparison with those without suppurative cholangitis. In cases with severe complication gastrointestinal bleeding or shock, these tendencies were more prominent. Furthermore, significant decrease in platelet count, C₃, C1INH and CH₅₀ Levels was observed. These abnormalities improved favorably after the appropriate biliary drainage. However, in patients with severe suppurative cholangitis, major complications occurred even after drainage procedures.
Because hypercoagulable state with decrease of antithrombin III levels was common in early postoperative days in such cases, these complications were supposed to be caused by disseminated intravascular coagulation. To prevent such complications, administration of antithrombin III concentrate preparation and low dose heparin was considered reasonable.

---

---

To read the PDF file you will need Adobe Reader installed on your computer.