J.Jpn. Surg. Soc.. 82(4): 378-385, 1981
Original article
EXPERIMENTAL STUDIES ON GASTRIC SECRETION AFTER MAJOR RESECTION OF THE LIVER
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From the First Department of Surgery, Faculty of Medicine, Mie University (Director: Prof. R. Mizumoto) Kohichi Furuta |
Fasting serum gastrin level significantly increased 3 to 7 weeks after the major resection of the liver.
The levels of acid secretion in Heidenhain pouch and serum gastrin in peripheral venous blood increased significantly to 192% and 109% respectively after 70% hepatectomy, compared to the preoperative levels, by the test-meal stimulation.
Gastrin turnover in the liver, presented by the ratio of serum gastrin level in peripheral venous blood to that in portal venous blood, did not show any changes after the major hepatectomy.
The increased gastric secretion after the major hepatic resection was completely inhibited by the administration of secretin.
These results revealed that gastric secretion increased after the major resection of the liver and suggest that it may be due to hypersecretion of the stomach itself and to decrease of secretin-inhibition, but not to decrease of gastrin turnover in the liver.
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