J.Jpn. Surg. Soc.. 82(2): 149-161, 1981

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Original article

TREATMENT OF ACUTE ISCHEMIC HEPATIC FAILURE WITH ATP-MgCl₂ ADMINISTRATION

The present study was undertaken to determine the effect of adenosine triphosphate-magnesium chloride (ATP-MgCl₂) infusion after 60 minutes of total hepatic ischemia and to elucidate its mechanism. Following the release of the hepatic vascular occlusions, ATP-MgCl₂ (50 μmoles) was given intravenously to treated dogs, and saline to the controls. The survival rate was 100% among the ATP-MgCl₂ treated animals and 40% among the controls, respectively (p＜0.01). Various hepatic functions including indocyanin green (ICG) test and reticuloendothelialsystem (RES) phagocytic activity measurement, hepatic cellular ATP levels, water contents and electrolytes of hepatic tissues were measured 90 minutes following the release of 60 minutes of ischemia. ICG test and RES function were greatly impaired following ischemia, and these function significantly improved with ATP-MgCl₂ treatment. These increased survival and improved hepatic functions indicate beneficial effect of ATP-MgCl₂ administration after ischemia. Furthermore, ATP level and energy charge were significantly decreased after ischemia, however, ATP level increased and the energy charge returned towards normal following ATP-MgCl₂ administration. The change of Na⁺, K⁺ and water contents in hepatic tissues showed that increase of water content as well as increase of Na⁺ content occured following hepatic ischemia and that this ischemically induced increased of intracellular water and Na⁺ contents were decreased towards normal with ATP-MgCl₂ administration.
following hepatic ischemia. The present experimental results may suggest important implications of ATP-MgCl₂ for organ preservation, management of postischemic acute hepatic failure and multiple systems failure.

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