J.Jpn. Surg. Soc.. 82(1): 96-107, 1981
Original article
THE EFFECT OF INTESTINAL BACTERIA ON ACUTE SIMPLE INTESTINAL OBSTRUCTION
－WITH SPECIAL REFERENCE TO GERM FREE ANIMAL－
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The First Department of Surgery, Nippon Medical School Akinori Bessho |
In this experiment, simple obstruction was set up in the lower small intestine of germ free mice and mixed contaminated mice associated with E. coli, S. faecalis, S. aureus, B. fragilis and C. perfringens, which were isolated from conventionalized mice and the mean survival time, the trend of the number of bacteria in the upper area before the obstruction in the intestine, and the pathohistological examinations of intestines were observed. Moreover the detection of endotoxin in the systemic blood number of bacteria in the upper area before the obstruction in the intestine, and the pathohistological examinations of intestines were observed. Moreover the detection of endotoxin in the systemic blood and in the abdominal cavity was performed and the analysis of the secondary bile acids in the upper area before the obstruction in the intestine was carried out.
This experiment suggests that in a simple intestinal obstruction as well as strangulation intestinal obstruction, damage of intestinal mucosa results in an increase of intestinal bacteria and endotoxin which are absorbed into the portal vein and this leads to portal endotoxemia which develops into systemic endotoxemia accompanied by hepatic insufficiency caused by the intestinal obstruction.
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