[Abstract] [Full Text PDF] (in Japanese / 7949KB) [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 81(12): 1505-1519, 1980


Original article

STUDIES ON PLATELET SPECIFIC β-THROMBOGLOBULIN IN SURGERY

First Department of Surgery, Gifu University School of Medicine (Director: Prof.K .Inada)

Haruyuki Senda

Plasma β-thromboglobulin (β-TG) level and platelet aggregate ratio were measured in patients with various diseases, and their changes were investigated in patients who underwent various operations. The following results were obtained.
1) Measurement of plasma β-TG level is effective for diagnosis of peripheral vascular diseases and it is possible to predict progress of the disease by continuous measurement.
2) Plasma β-TG level elevates temporarily during the operation, but recovers to normal range within 24 hours postoperatively.
3) The factors which are considered to be related to elevation of plasma β-TG level during the operation and the postoperative period are as follows.
a) surgical intervention, b) blood transfusion, c) thromboembolic complication, d) acute renal failure, e) cardiopulmonary bypass, f) grafting of synthetic prosthesis, and g) disseminated intravascula coagulation
4) The correlation between plasma β-TG level and platelet aggregate ratio is not determined, though, when plasma β-TG level elevates, platelet aggregate ratio decreases frequently.
5) During the postoperative period, suppression of the platelet function due to consumption of strage pool is common, and intervals of several days are neccessary for its recovery.
6) Continuous and simultaneous measurement of plasma β-TG and platelet aggregate ratio is useful tool for better understanding of the platelet function in vivo.


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