J.Jpn. Surg. Soc.. 81(10): 1332-1341, 1980

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Original article

AUTOTRANSPLANTATION OF PANCREATIC MICROFRAGMENTS IN TOTALLY PANCREATECTOMIZED DOGS
－EFFECTS OF THE VOLUME OF PANCREATIC FRAGMENTS ON THE METABOLIC RESPONSES IN TOTALLY PANCREATECTOMIZED DOGS－

In totally pancreatectomized dogs, the pancreatic microfragments were autotransplanted to the splenic pulp. A relationship between the volume of pancreatic fragments and the metabolic responses was studied. One month and 3 months after transplantation, the glucose tolerance test (0.5 g/kg) and the arginine tolerance test (0.75 g/kg) were performed in normoglycemic dogs. The following results were obtained.
1) Diabetes were ameriorated in dogs receiving the microfragments of more than half of the entire pancreas.
2) One month after transplantation, the glucose tolerance curves showed slightly higher peak values and a slower decline of glucose levels as compared to normal controls. The insulin levels corresponded to the glucose tolerance test were declined in all normoglycemic dogs. The mean K value and the insulinogenic index in the transplanted dogs were significantly less than those of normal dogs. The plasma glucagon levels were also declined in the arginine tolerance test.
3) Three months after transplantation, the glucose tolerance curves remained abnormal but showed no significant difference compared with that of the 1 month after transplantation. Howeve the insulin levels were lower than the values of 1 month after transplantation. The plasma glucagon levels in 3 months after transplantation were increased more than the values of 1 month after transplantation.

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