J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 8204KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 81(10): 1267-1281, 1980

Original article

STUDIES ON LIPOPROTEIN X (LP-X)
－ITS PRODUCTION AND CLINICAL SIGNIFFICANCIES－

2nd Department of Surgery, Tokyo Medical and Dental University

Toshio Fujihata

Determination of LP-X test was carried out in sera from 797 specimens with disturbance of live function. Forty-four specimens (22 patients) showed LP-X positive, in which 15 cases diagnosed by means of biopsies, operations and autopsies were all cholestatic diseases. Others remain still unknown.
All of 44 cases with hepatobiiiary cancers showed LP-X positive. In 75 patients suffering from extrahepatic obstruction, including the above 44, 68 cases (91 %) were positive.
Ligation of the common bile duct without cholecystectomy in 2 dogs revealed that LP-X was detecterl in the plasma within 72 hours. Following an increase in LP-X concentration in plasma for certain period, it decreased to be undetectable. Dogs died a few days later.
LP-X appeared within 30 minutes after intravenous injections of human native bile into a healthy dog.
Results
1. It is supposed that LP-X is sythesized by pathophysiological mixture of refluxed bile with plasma, so this synthesis is not concerned with the metabolic pathways of the liver.
2. The LP-X test is the most sensitive and specific to demonstrate or exclude cholestasis.

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