J.Jpn. Surg. Soc.. 81(8): 714-723, 1980

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Original article

IMMUNE RESPONSE OF REGIONAL LYMPH NODES IN PATIENTS WITH LUNG CANCER

To clarify immune response of regional lymphnode cells (RLNCs) in 30 patients with lung cancer, T cell population, phytohemagglutinin (PHA), Concanavalin A (ConA) stimulation, T cell subpopulation bearing lg-G Fc receptor (TG cell) and HLA antigens were tested in the clinical stage, histology and the location of lymphnodes.
T cell population, PHA and ConA response rate in RLNCs of stage I patients were grossly same as those of benign lung diseases, but were higher than those of stage III patients with statistical difference (P＜0.025, P＜0.005).
Among three histological types of lung cancer, RLNCs of adenocarcinoma had the highest rate inT cell population, PHA and ConA response.
As for the location of lymphnodes, the closer was the lymphnodes to the tumor, the higher was its T cell population, and vice versa. However there was no difference in PHA and ConA response.
All lung cancer patients revealed a significant increase of TG cell in RLNCs and in their peripheral blood lymphocytes (PBLs), compared with PBLs in normal subjects.
In lung cancer patients both RLNCs and PBLs had the same HLA-A and HLA-B antigens, but they had the increased frequency of Blank antigen at both A and B loci compared with controls.

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