J.Jpn. Surg. Soc.. 81(8): 701-713, 1980

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Original article

IMMUNOLOGICAL STUDIES IN CHRONIC OCCLUSIVE ARTERIAL DISEASES WITH A SPECIAL REFERENCE TO CELLMEDIATED IMMUNITY

Immunological studies were performed on 20 patients with aortitis syndrome, 54 patients with Buerger's disease and 53 patients with arteriosclerosis obliterans. Delayed hypersensitivity, T-cell, B-cel, stimulation index by phytohemagglutinin and leucocyte migration inhibition test were investigated. Following results were obtained.
1) Incidence of anergy to tuberculin was high in aortitis syndrome counting 75 per-cent in active stage.
2) Incidence of anergy to PHA was high in aortitis syndrome in active stage. It was high in patients with ischemic ulcer in two other diseases.
3) Negative response to DNCB was found in half of aortitis syndrome and all with ulcer in Buerger's disease.
4) Significant decrease of T-cell was found in aortitis syndrome.
5) No significant difference was found in B-cell per-cent between three groups.
6) Stimulation index was significantly decreased in aortitis syndrome, prominent in active stage. Significant correlation was found between T-cell per-cent and stimulation index.
7) Leucocyte migration inhibition test was positive in two cases with aortitis syndrome, suggesting of presence of sensitivity to aortic tissue component.
It was concluded that cell-mediated immunity was significantly decreased in patients with aortitis syndrome, although participation of the immunological mechanism in development of the disease was not denied in both Buerger's disease and arteriosclerosis obliterans.

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