[
Abstract]
[
Full Text PDF] （in Japanese / 9061KB）
[Members Only And Two Factor Auth.] J.Jpn. Surg. Soc.. 81(6): 481-493, 1980
Original article
EXPERIMENTAL STUDIES ON THE GASTRIC MUCOSAL CHANGES AFTER SELECTIVE PROXIMAL VAGOTOMY WITH OR WITHOUT PYLOROPLASTY
Compared with the gastric mucosa in dogs with ligation of left gastric artery, effects of pyloroplasty upon the gastric mucosa in those with SPV were histologically studied, and, secondly, experiments to induce gastric ulcer by Indomethacin load in such dogs above described were carried out. The results obtained were as follows. After vagotomy, release of pepsinogen from chief cells was inhibited with reduction in the acid secretory function by parietal cells. The positive PAS stained substance in the superficial epithelial cell as one of the defense factors was unchanged after vagotomy, while it was decreased by ligation of left gastric artery and remarkably decreased by additional pyloroplasty. Experimental gastric ulcer tended to occur most frequently in case of SPV with pyloroplasty. These findings suggested that the offense and defense factors were well balanced in the gastric mucosa in case of SPV alone, however the balance was lost in case of SPV with pyloroplasty.
It was concluded from these studies that SPV without pyloroplasty was more appropriate than SPV with pyloroplasty as a surgical treatment of duodenal ulcer without stenosis.
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