J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 6194KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 81(5): 407-415, 1980

Original article

PATHOGENESIS OF ACUTE ANTRAL ULCER OF THE STOMACH
－CLINICAL STUDIES ON GASTRIC ACID AND GASTRIN－

*) Oiwa Castro-intestinal Hospital, Koga, Fukuoka, Japan
**) Department of Surgery II, Kyushu University, School of Medicine, Fukuoka, Japan

Toshio Oiwa*), Keizo Sugimachi**)

The pathogenesis of acute antral ulcer of the stomach remains still obscure. In this study, four cases in which the course of acute gastric ulceration is observed well and one case of acute gastritis with hemorrhagic erosion have been reported. The secretion of gastric acid and gastrin, as well as gastrofluoroscopy and gastroendscopy are observed through the course of ulcer formation. Gastrin has no remarkable change in all the course of acute ulcer formation, however, secretion of gastric acid has conspicously increased preceding by formation of acute gastric ulcer. On the contrast, no hyper secretion of gastric acid is observed in one case of acute gastritis. These results strongly suggest that hyper secretion of gastric acid may be an important role in the pathogenesis of the acute gastric ulceration of the human stomach, and moreover, hyper secretion of gastric acid may depend on not gastric phase but on cephalic phase.

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