J.Jpn. Surg. Soc.. 81(5): 397-406, 1980

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Original article

STUDIES ON THYROID AUTOANTIBODIES IN PATIENTS WITH THYROID DISEASES

Thyroid autoantibodies and peripheral lymphocyte subpopulations were examined in 178 patients, who consisted of 62 patients with chronic thyroiditis, 19 with Basedow's diseases, 40 with thyroid cancer, 54 with thyroid adenoma, and 3 with subacute thyroiditis.
The incidence of both antithyroid microsomal hemmagglutination antibody (MCHA) and antithyroglobulin hemmagglutination antibody (TGHA) was 93.2%, and 65.6% in chronic thyroiditis as well as 93.3% and 44.4% in Basedow's disease, respectively. The patients with both diseases had also high titers of MCHA and TGHA. On the other hand, MCHA and TGHA in thyroid cancer patients were detected in 34.3% and 21.6%, respectively; and 30.0%, 6.0% in thyroid adenoma. Their autoantibody titers were, however, lower than that of two diseases mentioned above. TGHA was found more frequently in thyroid cancer than in thyroid adenoma. There was observed close correlation between lymphocyte infiltration in the normal thyroid tissues and TGHA frequently in thyroid cancer patients and further, positive correlation between lymphocyte infiltration and TGHA or MCHA in thyroid adenoma. Antithyroid autoantibodies in thyroid cancer patients did not correlate with lymphocyte infiltration surrounding cancer focus, intraglandular metastases, and lymph node metastases. The percentage and exact number of peripheral T and B lymphocytes in various thyroid diseases did not differ practicaly from normal volunteers. Thyroid autoantibodies titers did not correlate with peripheral T and B lymphocyte counts.

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