J.Jpn. Surg. Soc.. 81(3): 247-255, 1980
Original article
EXPERIMENTAL STUDIES ON THE INFLUENCE OF LIGATION OF THE COMMON BILE DUCT WITH PANCREATIC DUCT LIGATION UPON GASTRIC ACID SECRETION
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Department of Surgery, Tohoku University School of Medicine, Sendai Iwao Sasaki, Takeshi Sekine, Jin-ichi Kameyama, Satoshi Momono, Toshio Sato |
The mean 24-hr acid output from the Heidenhain pouches showed a significant increase in 3 of 5 dogs, with the increase rate of 160-586%, in ligation of the common bile duct, and in all of 5 dogs, with the increase rate of 199-564%, in ligation of the common bile duct with pancreatic duct ligation. On the other hand, serum gastrin levels at the time of fasting showed no significant change, but in response to a test meal significantly decreased in both ligation of the common bile duct and common bile duct with pancreatic duct ligation. Serum secretin levels in ligation of the common bile duct showed no significant change, while in ligation of the common bile duct with pancreatic duct ligation serum secretin levels showed a significant increase and paralleled to acid output. Intraduodenal pH was at low value in both ligation of the common bile duct and common bile duct with pancreatic duct ligation.Also, peptic ulcer developed in 2 of 5 dogs in both ligation of the common bile duct and common bile duct with pancreatic duct ligation.
These results suggest that gastric hypersecretion induced by ligation of the common bile duct and common bile duct with pancreatic duct ligation is not related simply to release of gastrin, and further hypersecretinemia induced by ligation of the common bile duct with pancreatic duct ligation may be secondary to gastric hypersecretion.
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