J.Jpn. Surg. Soc.. 81(1): 47-54, 1980

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Original article

EVALUATION OF HAPTOGLOBIN FOR THE TREATMENT OF HEMOLYSIS OCCURED UNDER THE OPEN HEART SURGERY USING EXTRACORPOREAL CIRCULATION

Hemoglobin (Hb) released into plasma binds firmly to the α-2-mucoprotein, haptoglobin (Hp), to form Hp-Hb complex, which inhibits hemoglobin from escaping through the glomerulm preventing renal tubular injury.
Haptoglobin produced pharmaceutically was administered as a treatment of hemolysis in the patients undergone open heart surgery with extracorporeal circulation. In twenty one patients 4000 units of Hp were given into the cardiopulmonary bypass circuits. In fifteen patients who had not received Hp, serum free Hb, Hb other than Hp-Hb complex, appeared at the end of the operations up to the level of 9.0 mg/dl, which indicated the deficiency of Hp at same level.
In the group treated with Hp, serum free Hp maintained higher level than total Hb did. In other words, serum free Hp maintained its positive level throughout the operation, and serum free Hb did not appeared after the administration of Hp.
Administration Hp prevented gross hemoglobinuria effectively and preserved the postoperative renal function.

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