J.Jpn. Surg. Soc.. 80(3): 232-247, 1979
Original article
EXPERIMENTAL AND CLINICAL STUDIES IN TOTAL PARENTERAL NUTRITION FOR THE LIVER DISEASE PATIENTS
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The 1st Department of Surgery, School of Medicine, Chiba University (Director : Prof. Kenjiro Itoh) Kazuhide Ohno |
In animal experiment, hepatic lesions were induced by successive administration of Dimethylnitrosamine. After one month of final administration, Total Parenteral Nutrition with three different amino acid solutions, each for one week with three days interval of oral feeding, was started. Glucose as a main calorie source and no fat emulsion were used. Serum GOT, GPT, Alkaline phosphatase, ammonia, aminogram and nitrogen balance studies were performed. The abnormal aminogram tended to become normal when FO-80 type amino acid was used as nitrogen source during Total Parenteral Nutrition. The same results were observed clinially during Total Parenteral Nutrition on cirrhotic patients with the same amino acid formula.
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