J.Jpn. Surg. Soc.. 28(10): 1187-1199, 1928
Others
ABOUT THE ACTION UPON CELLS OF LIVING ORGANISMS BY NONSPFCIAL=ANTIGEN.
The 2nd Report of the Biological Test as to the Nonspecial-Antigen.
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From the 2nd Sugigal Clinik (in charge of Prof. Dr. H. Suguro) of the Osaka Medical College. Shizumi Kuroda M.D. |
At 30 minutes after the hypodermic injection, 1.0 ccrn of Bacteriaemulsion (amounting ca. 0.0035 ccm of bacteria), of Staphylococcus pyogenus albus, caltivated 24 hours on the neutralagar, is injected into V. jugularis of guinea-pigs.
At each quater, half, l, 2, 4 and 6 hours after the transportation of Bacteria-Emulsion in V. jugularis, I observed the states of phagocytosis and the change in number of phagocytisms s. l. in each 1.0 cmm of circulating blood.
As the contrast, 1.0 ccrn of Bacteria-Emulsion only, the same nature as above mentioned, is injected into V. jugularis of another group of guinea-pigs, which has not been treated with the Nonspecial-Antigen.
The results obtained by the comparison of the two experiments, one treated with the Nonspecial-Antigen and the other without, is as follows：一
1. The phagocytosis in circulating blood of the guinea-pigs which were treated with Nonspccial-Antigen, is greater than that of the guinea-pigs, which received no treatment.
2. Although, the phagocytosis of the guinea-pigs, which were treated with the Nonspecial-Antigen, increased with the quantities of the Non special-Antigen (from 0.08 to 0.1 ccm) used, but the increasments are not in the exact proportion with the quantities.
3. The phagocytisms (or leucocytes) s. 1. in circulating blood of the guinea-pigs, treated with the Nonspecial-Antigen, is in all sum greater than that of the guinea-pigs which were not treated with the Nonspecial-Antigen.
4. By the foregoing results, both the phagocytosis and the phagocytisms in circulating blood of the guinea-pigs, treated with a certain quantity of the Nonspecial-Antigen, increased more than that of the guinea-pigs which received no treatment, that is to say, the Nonspecial-Antigen has a special property of action upon cells of living organisms.
The reason why the phagocytosis is stronger, is rlue to the special property of action upon cells of living organisms by the Nonspecial-Antigen, and therefore this results makes our conception of the 1st report more reliable.
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