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J.Jpn. Surg. Soc.. 119(3): 299-305, 2018
TRANSLATIONAL RESEARCH ON CHILDHOOD CANCER CONDUCTED BY SURGEONS
In multidisciplinary therapy for childhood cancer, the main role of surgeons is performing resection as local therapy. When surgeons gain a better understanding of the total management of cancer therapy and tumor biology, they could provide advanced tailored therapy including quality of life-based and organ-preserving surgery. Therefore, translational research on childhood cancer conducted by surgeons is meaningful and could lead to the development of advances in treatment. We introduce two of our translational research projects on neuroblastoma, the most common extracranial solid tumor in children. One investigates the effects and pathways of MEK inhibitors, which inhibit the RAS-ERK pathway, as a new molecular-targeted therapy for refractory neuroblastoma. The other is the tumor-homing ability of human mesenchymal stem cells in a transgenic TH-MYCN mouse model of neuroblastoma.
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