J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text HTML] [Full Text PDF] （in Japanese / 281KB） [Members Only]

J.Jpn. Surg. Soc.. 114(5): 251-255, 2013

Feature topic

KAMPO MEDICINE FOR THE TREATMENT OF ADVERSE EFFECTS CAUSED BY ANTICANCER DRUGS

1) Advanced Surgery Center, Sapporo Higashi Tokushukai Hospital, Japan
2) Faculty of Pharmaceutical Sciences, Hokkaido University, Japan
3) Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, Japan

Toru Kono1), Hiroshi Takeda2), Yasuhito Uezono3)

In contrast to conventional single-target drugs, multicomponent Kampo medicines are designed to achieve therapeutic effects through multiple drug targets. This article discusses recent advances in mechanistic studies and the clinical effects of eight representative Kampo formulations (Rikkunshito, Hangeshashinto, Daikenchuto, Goshajinkigan, Yokukansan, and the tonics Hochuekkito, Juzentaihoto, and Ninjinyoeito) for the treatment of adverse effects caused by anticancer drugs such as anorexia, oral mucositis, diarrhea, neurotoxicity, abnormal behavior, malaise, weakness, and thrombocytopenia, which Western pharmaceuticals fail to address adequately.

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