J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 499KB） [Members Only And Two Factor Auth.][Back to Search Results]

J.Jpn. Surg. Soc.. 94(10): 1071-1077, 1993

Original article

CHANGES OF SERUM INTERLEUKIN 6 (IL6) AND ACUTE PHASE PROTEIN AFTER HEPATECTOMY IN PATIENTS WITH CHRONIC LIVER DISEASE

1) Department of Surgery, The Center for Adult Diseas, Osaka, Japan
2) Department of Obstetrics and Gynecology, Osaka University Medical School, Osaka, Japan

Seizo Masutani1), Yo Sasaki1), Shingi Imaoka1), Ichiro Ohashi1), Osamu Ishikawa1), Takeshi Iwanaga1), Masaaki Yamaguchi2)

We examined the changes in serum levels of interleukin 6 (s-IL6) and acute phase protein (APP) during perioperative periods in patients with or without chronic liver disease (CLD) who underwent hepatectomy or other surgeries. The elevation of s-IL6 on the first postoperative day was only correlated with preoperative values of indocyanine green retention test (ICG-R15) (r=0.56, p＜0.01), and not concerned with any operative factors.
We devided the patients into the following three groups; the patients with CLD undergoing hepatectomy (n=21, group A), the patients without CLD undergoing hepatectomy (n=7, group B), and the patients without CLD undergoing surgeries other than hepatectomy (n=7, group C). The values of s-IL6 on preoperative day, 1st, 4th, and 7th days after surgery in group A were significantly higher than the corresponding values in group C (p＜0.05).
Among the hepatectomy groups, the serum levels of APP on the 4th day after surgery were significantly higher than those on preoperative day.
We concluded that the changes in s-IL6 after hepatectomy were strongly concerned with preoperative liver function, especially with values of ICG-R15. However, it seemed that the induction of APP was negatively correlated with the preoperative liver function.

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