J.Jpn. Surg. Soc.. 84(8): 679-691, 1983
Original article
NONSPECIFIC CELL-MEDIATED IMMUNITY IN GASTRIC CANCER PATIENTS
－With Special Reference to Immuno-Reactivity of the Regional Lymph Node and Preoperative Immunotherapy－
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Second Department of Surgery, Gunma University School of Medicine, Maebashi, Japan Masaaki Takeshita |
The studies were undertaken on the parameters such as skin test (PHA, PPD, Cadida and SK-SD), T-cell subpopulation and lymphocyte blastoformation. And concerning the regional lymph node, percentage of T-cell and blastoformation were examined.
The following results were obtained.
1) There were correlations between the nonspecific parameters (PHA skin test, count of active T-cell and PHA blastoformation) and the staging according to the Japanese Research Society for Gastric Cancer.
2) There were also correlations between the stage and the percentage of T-cell, PHA blastoformetion with and without autoserum in the immunity of the proximal regional lymph node.
3) Correlations between the PHA blastoformation in the proximal lymph node and the nonspecific parameters such as PHA, Candida skin test, count of the active T-cell and PHA blastoformation in the peripheral lymphocyte were observed.
4) The immunity of the distant regional lymph node was impaired in the patients of stage IV and III with 4 metastatic lymph nodes or more.
5) Preoperative administration of PSK prevented impairment of cell-mediated immunity after operation.
6) Patients administrated lentinan before operation got rid of depression of immunity in the proximal regional lymph node.
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