J.Jpn. Surg. Soc.. 83(5): 457-467, 1982

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Original article

CHARACTERISTICS OF HUMAN GASTROINTESTINAL AND BREAST CANCER XENOGRAFTS IN NUDE MICE; WITH SPECIAL REFERENCE TO CARCINOEMBRYONIC ANTIGEN AND CHEMOSENSITIVITY

Biological characteristics of human gastrointestinal and breast cancer xenografted in nude mice in our clinic were evaluated in the aspects of morphology, karyotype, growth rate, carcinoembryonic antigen (CEA) and chemosensitivity. Successful transplantation was obtained in 24 cases (stomach 13, breast 5, colorectal 4) out of 63 inocula tried. The most contribulory factor to the transplantability was cellularity of the specimen inoculated.
The cancer xenografts preserved histologically their original characteristics and also maintained human chromosomal patterns. Although growth rate of each cancer differed from 5 to 30 days in the volume doubling time, the rate of a cancer remained identical at different passage levels. CEA was found in sera of nude mice bearing human cancer and increased in parallel with the change of tumor volume. CEA level was high in sera of mice with rectal cancer and low in pancreatic and breast cancer. The level in each cancer remained similar even after repeated transfers. The response of 9 chemotherapies in 7 human cancer xenografts was well correlated with that of each donor patient. In general, the human cancer xenografts in nude mice preserved well their biological characteristics.
It is concluded that the human cancer xenograft/nude mouse system is the useful model for various kinds of experimental chemotherapies.

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