J.Jpn. Surg. Soc.. 79(11): 1459-1472, 1978

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Original article

SERUM LIPORPOTEIN-X (LX-P) (II) LX-P DEMONSTRATED 10% FAT EMULSION

Serum lipoprotein-X (LP-X) characterizing obstructive jaundice was often demonstrated following administration of 10% fat emulsion (Intralipid, Intrafat) by the method of immunoelectrophoresis using anti-Apo C serum and Sudan Black prestain agar electrophoresis.
Similar changes of serum lipids level to those of obstructive jaundice were also obtained in "fat emulsion induced LP-X" serum, the increase of both lecithin and total cholesterol and the decrease of percent cholesterol ester. Electromicroscopic examination revealed the lamellar structures which had a tendency to making the myeline shape appearance in those samples.
Studies on the appearance of "fat emulsion induced LP-X" were carried out. The results were as follows.
1) Cholestasis was not made due to the administration of fat emulsion.
2) Fat emulsion accentuated the activity of serum lecithin-cholesterol acyltransferase (LCAT), but no relation between LCAT activity and appearance of LP-X was found.
3) LP-X-like abnormal lipoprotein was demonstrated in normal serum following the in vitro mixture with fat emulsion.
According to these results, it was concluded that "fat emulsion induced LP-X" might be nonenzymatically synthesized as the result of interaction between the abundant lecithin and cho­lesterol contained in fat emulsion and the serum Apo-C and albumin.
It is important to clarify what the above mentioned fact might mean in clinical aspect.

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